Furan is commonly found in several kinds of heat-treated foods, the existence of furan in food causes public health issues. The current research examines the preventive impact of glutathione on liver, kidney function, and tumor markers against furan-induced injury in mice. Male albino mice were divided into seven groups: a control (G1), G2 (0.5mg furan/kg b.w./day), G3 (1 mg furan/kg b.w./day), G4 (2 mg furan/kg b.w./day), G5 (4 mg furan/kg b.w./day), G6 (2 mg furan/kg b.w./day +500 mg glutathione/kg/day), and G7 (4 mg furan/kg b.w./day +500 mg glutathione/kg/day). At the end of the study, after 8 weeks, the anesthetized and sacrificed were done, and then the different tests were conducted. Results: Furan significantly increased hepatocyte damage in mice, as evidenced by increased activities of aminotransferase (AST) and alanine aminotransferase (ALT) after a 2mg/kg/day dose. Furan promoted oxidative stress due to elevated malondialdehyde levels, occurring at various furan dosages (0.5, 1, 2, and 4mg/kg/day). The study found that pretreatment with glutathione at 500 mg/kg/day reduced AST, ALT, and MDA activities in mice, while furan levels did not negatively impact kidney functions. It should be noted that all levels of furan increased tumor markers [Alpha Fetoprotein (AFP)] compared to the control (3.1 ng/ml), whereas glutathione reduced the level of AFP in groups taking furan at (2 and 4 mg/kg) to range (3.5–3.6 mg/ml) compared to (4.6–4.8 mg/ml) for the same groups taking furan at (2 and 4 mg/kg) without glutathione. Glutathione's protective effects against furan-induced hepatocyte damage may be due to its exceptional capacity to scavenge free radicals. Glutathione, with its strong antioxidant properties, has the potential to be a promising therapeutic and preventive agent for diseases induced by furan compounds.
Ibrahim, I., Saleh, H., & Hamouda, A. (2024). Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan. Food Technology Research Journal, 3(2), 79-80. doi: 10.21608/ftrj.2024.346574
MLA
Ibrahim Ibrahim; Hend Saleh; Alshaimaa Hamouda. "Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan". Food Technology Research Journal, 3, 2, 2024, 79-80. doi: 10.21608/ftrj.2024.346574
HARVARD
Ibrahim, I., Saleh, H., Hamouda, A. (2024). 'Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan', Food Technology Research Journal, 3(2), pp. 79-80. doi: 10.21608/ftrj.2024.346574
VANCOUVER
Ibrahim, I., Saleh, H., Hamouda, A. Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan. Food Technology Research Journal, 2024; 3(2): 79-80. doi: 10.21608/ftrj.2024.346574
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